Updated October 6, 2026
This is the Week 5 betting line for the Detroit Lions (2-2) against the Arizona Cardinals (1-3) at State Farm Stadium on Sunday at 4:25 p.m. ET.
DraftKings has DET -4.5, over/under 54.5, ARI +180, DET -218. FanDuel has ARI +4.5, over/under 53.5, ARI +198. BetMGM has ARI +4.5, over/under 54, ARI +200. Caesars has ARI +5, over/under 54, ARI +199. Fanatics has ARI +5, over/under 54.5, ARI +200.
| DraftKings | FanDuel | BetMGM | Caesars | Fanatics | |
|---|---|---|---|---|---|
| Spread | DET -4.5 | ARI +4.5 | ARI +4.5 | ARI +5 | ARI +5 |
| Over/Under | 54.5 | 53.5 | 54 | 54 | 54.5 |
| ARI ML | +180 | +198 | +200 | +199 | +200 |
| DET ML | -218 | (-) | (-) | (-) | (-) |
What the moneyline numbers mean
A moneyline is the price to pick a winner in football gambling. It is not the spread. A minus number is the favorite. A plus number is the underdog.
If a team is listed at -100, a $100 wager on that team returns $100 profit if it wins, plus the original $100. If a team is listed at +100, a $100 wager returns $100 profit if it wins. A number such as -298 means you risk $298 to win $100. A number such as +240 means a $100 wager wins $240 if that team wins.
This page reports the posted Detroit Lions line for readers who already choose to bet. Legal sports betting is a personal decision. We are not urging anyone to wager.
As of October 6, 2026.
